Sleep quality and asthma control and quality of life in non-severe and severe asthma.

TitleSleep quality and asthma control and quality of life in non-severe and severe asthma.
Publication TypeJournal Article
Year of Publication2012
AuthorsLuyster FS, Teodorescu M, Bleecker E, Busse W, Calhoun W, Castro M, Chung K F, Erzurum S, Israel E, Strollo PJ, Wenzel SE
JournalSleep Breath
Volume16
Issue4
Pagination1129-37
Date Published2012 Dec
ISSN1522-1709
KeywordsAdministration, Inhalation, Administration, Oral, Adrenal Cortex Hormones, Adult, Asthma, Cohort Studies, Comorbidity, Disorders of Excessive Somnolence, Female, Gastroesophageal Reflux, Humans, Male, Middle Aged, Polysomnography, Quality of Life, Retrospective Studies, Sleep, Sleep Apnea, Obstructive, Young Adult
Abstract

PURPOSE: The effect of sleep quality on asthma control independent from common comorbidities like gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA) is unknown. This study examined the association between sleep quality and asthma control and quality of life after accounting for OSA and GERD in non-severe (NSA) and severe (SA) asthma.

METHODS: Cross-sectional data from 60 normal controls, 143 with NSA, and 79 with SA participating in the Severe Asthma Research Program was examined. Those who reported using positive airway pressure therapy or were at high risk for OSA were excluded.

RESULTS: Both SA and NSA had poorer sleep quality than controls, with SA reporting the worst sleep quality. All asthmatics with GERD and 92% of those without GERD had poor sleep quality (p = 0.02). The majority (88-100%) of NSA and SA participants who did not report nighttime asthma disturbances still reported having poor sleep quality. In both NSA and SA, poor sleep quality was associated with worse asthma control and quality of life after controlling for GERD and other covariates.

CONCLUSIONS: These results suggest that poor sleep quality is associated with poor asthma control and quality of life among asthmatics and cannot be explained by comorbid GERD and nighttime asthma disturbances.

DOI10.1007/s11325-011-0616-8
Alternate JournalSleep Breath
PubMed ID22102290