Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.

TitleSevere asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.
Publication TypeJournal Article
Year of Publication2012
AuthorsJarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung K F, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague GW, Wenzel SE, Busse WW
Corporate AuthorsNHLBI Severe Asthma Research Program(SARP)
JournalAm J Respir Crit Care Med
Volume185
Issue4
Pagination356-62
Date Published2012 Feb 15
ISSN1535-4970
KeywordsAdolescent, Adult, Airway Remodeling, Asthma, Biological Markers, Bronchoscopy, Child, Clinical Protocols, Cohort Studies, Cross-Sectional Studies, Humans, Risk Factors, Severity of Illness Index
Abstract

The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.

DOI10.1164/rccm.201107-1317PP
Alternate JournalAm. J. Respir. Crit. Care Med.
PubMed ID22095547