Roadmap for investigating epigenome deregulation and environmental origins of cancer

TitleRoadmap for investigating epigenome deregulation and environmental origins of cancer
Publication TypeJournal Article
Year of Publication2018
AuthorsHerceg Z., Ghantous A., Wild C.P, Sklias A., Casati L., Duthie S.J, Fry R., Issa J.P, Kellermayer R., Koturbash I., Kondo Y., Lepeule J., Lima S.CS, Marsit C.J, Rakyan V., Saffery R., Taylor J.A, Teschendorff A.E, Ushijima T., Vineis P., Walker C.L, Waterland R.A, Wiemels J., Ambatipudi S., D. Esposti D, Hernandez-Vargas H.
JournalInternational Journal of Cancer
Volume142
Pagination874-882
Date PublishedMar 1
ISBN Number0020-7136
Accession Number28836271
KeywordsBiomarkers, CANCER, Environment, epigenetics, molecular mechanisms, perspectives, research gaps
Abstract

The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.

Short TitleInt J CancerInt. J. Cancer
Alternate JournalInternational journal of cancer