Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective

TitleOxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective
Publication TypeJournal Article
Year of Publication2018
AuthorsGhezzi P., Floridi L., Boraschi D., Cuadrado A., Manda G., Levic S., D'Acquisto F., Hamilton A., Athersuch T.J, Selley L.
JournalAntioxid Redox SignalAntioxidants and Redox SignalingAntioxidants & redox signaling
Volume28
Pagination852-872
Date PublishedMar 20
ISBN Number1523-0864
Accession Number28494612
Keywords*cytokines, *emotions, *Exposome, *genomics, *nanomaterials, *neuroendocrinology, *Nrf2, *proteomics, *xenobiotics
Abstract

SIGNIFICANCE: The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. Recent Advances: By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. CRITICAL ISSUES: The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. FUTURE DIRECTIONS: We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. Antioxid. Redox Signal. 28, 852-872.

Short TitleAntioxid. Redox Signal.
Alternate JournalAntioxidants & redox signaling