New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

TitleNew loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Publication TypeJournal Article
Year of Publication2013
AuthorsHorikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal RH, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P et al.
Corporate AuthorsMeta-Analyses of Glucose- and Insulin-related traits Consortium(MAGIC), Early Growth Genetics(EGG) Consortium
JournalNat Genet
Volume45
Issue1
Pagination76-82
Date Published2013 Jan
ISSN1546-1718
KeywordsAdult, Birth Weight, Blood Pressure, Body Height, Diabetes Mellitus, Type 2, Female, Fetal Development, Genetic Linkage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Newborn, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci
Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

DOI10.1038/ng.2477
Alternate JournalNat. Genet.
PubMed ID23202124