Maternal cholestasis during pregnancy programs metabolic disease in offspring.

TitleMaternal cholestasis during pregnancy programs metabolic disease in offspring.
Publication TypeJournal Article
Year of Publication2013
AuthorsPapacleovoulou G, Abu-Hayyeh S, Nikolopoulou E, Briz O, Owen BM, Nikolova V, Ovadia C, Huang X, Vaarasmaki M, Baumann M, Jansen E, Albrecht C, Jarvelin M-R, Marin JJG, Knisely AS, Williamson C
JournalJ Clin Invest
Date Published2013 Jul 1
KeywordsAdipose Tissue, White, Adolescent, Animals, Bile Acids and Salts, Blood Glucose, Case-Control Studies, Cells, Cultured, Cholestasis, Intrahepatic, Diet, Disease Susceptibility, Epigenesis, Genetic, Fatty Liver, Female, Homeostasis, Humans, Insulin, Lipid Metabolism, Liver, Male, Mice, Mice, Inbred C57BL, Obesity, Placenta, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Prenatal Nutritional Physiological Phenomena, Transcriptome

The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985-1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring.

Alternate JournalJ. Clin. Invest.
PubMed ID23934127