Geographical epidemiology of prostate cancer in Great Britain.

TitleGeographical epidemiology of prostate cancer in Great Britain.
Publication TypeJournal Article
Year of Publication2002
AuthorsJarup L, Best N, Toledano MB, Wakefield J, Elliott P
JournalInt J Cancer
Volume97
Issue5
Pagination695-9
Date Published2002 Feb 10
ISSN0020-7136
KeywordsBayes Theorem, Cluster Analysis, Great Britain, Humans, Male, Middle Aged, Poisson Distribution, Prostatic Neoplasms, Risk, Risk Assessment, Socioeconomic Factors, Urbanization
Abstract

Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was to examine the spatial variation of prostate cancer in Great Britain at ages 45-64 years. Spatial variation was examined across electoral wards from 1975-1991. Poisson regression was used to examine regional, urbanisation and socioeconomic effects, while Bayesian mapping techniques were used to assess spatial variability. There was an indication of geographical differences in prostate cancer risk at a regional level, ranging from 0.83 (95% CI: 0.78-0.87) to 1.2 (95% CI: 1.1-1.3) across regions. There was significant heterogeneity in the risk across wards, although the range of relative risks was narrow. More detailed spatial analyses within 4 regions did not indicate any clear evidence of localised geographical clustering for prostate cancer. The absence of any marked geographical variability at a small-area scale argues against a geographically varying environmental factor operating strongly in the aetiology of prostate cancer.

Alternate JournalInt. J. Cancer
PubMed ID11807800