Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

TitleGenome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Publication TypeJournal Article
Year of Publication2011
AuthorsSoler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M'en, Tang W, Zhai G, Zhao J H, Smith A V, Huffman JE et al.
Corporate AuthorsInternational Lung Cancer Consortium, GIANT consortium
JournalNat Genet
Volume43
Issue11
Pagination1082-90
Date Published2011 Nov
ISSN1546-1718
KeywordsChild, European Continental Ancestry Group, Genome-Wide Association Study, Humans, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests
Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

DOI10.1038/ng.941
Alternate JournalNat. Genet.
PubMed ID21946350