Genetic loci influencing kidney function and chronic kidney disease.

TitleGenetic loci influencing kidney function and chronic kidney disease.
Publication TypeJournal Article
Year of Publication2010
AuthorsChambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJL, Beckmann J, Bilo HJG, Bochud M, Brown MJ, Caulfield MJ, Connell JMC, H Cook T, Cotlarciuc I, Smith GDavey, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, van der Heide JJHoman, Hepkema BG, Hernandez-Fuentes M, Hyppönen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJF, Luan J'an, Luttropp K, Maréchal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MAJ, Shuldiner AR, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJE, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin M-R, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS
JournalNat Genet
Volume42
Issue5
Pagination373-5
Date Published2010 May
ISSN1546-1718
KeywordsBiological Transport, Creatinine, Cystatin C, Europe, Gene Expression Regulation, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Models, Genetic
Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

DOI10.1038/ng.566
Alternate JournalNat. Genet.
PubMed ID20383145
PubMed Central IDPMC3748585
Grant List091746 / / Wellcome Trust / United Kingdom
BB/F020481/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
G0400874 / / Medical Research Council / United Kingdom
G0600420 / / Medical Research Council / United Kingdom
G0600705 / / Medical Research Council / United Kingdom
G0601966 / / Medical Research Council / United Kingdom
G0700931 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
G0801056 / / Medical Research Council / United Kingdom
G9521010 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom
MC_U106188470 / / Medical Research Council / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
PHCS/C4/4/016 / / Department of Health / United Kingdom
Z01 AG000675-02 / / Intramural NIH HHS / United States