The exposome in practice: Design of the EXPOsOMICS project

TitleThe exposome in practice: Design of the EXPOsOMICS project
Publication TypeJournal Article
Year of Publication2017
AuthorsVineis P., Chadeau-Hyam M., Gmuender H., Gulliver J., Herceg Z., Kleinjans J., Kogevinas M., Kyrtopoulos S., Nieuwenhuijsen M., Phillips D.H, Probst-Hensch N., Scalbert A., Vermeulen R., Wild C.P
JournalInternational Journal of Hygiene and Environmental Health
Volume220
Pagination142-151
Date PublishedMar
ISBN Number1438-4639
Accession Number27576363
Abstract

EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).

Short TitleInt. J. Hyg. Environ. HealthInt. J. Hyg. Environ. Health
Alternate JournalInternational journal of hygiene and environmental health