Drinking water disinfection byproducts, genetic polymorphisms, and birth outcomes in a European mother-child cohort study

TitleDrinking water disinfection byproducts, genetic polymorphisms, and birth outcomes in a European mother-child cohort study
Publication TypeJournal Article
Year of Publication2016
AuthorsKogevinas M., Bustamante M., Gracia-Lavedan E., Ballester F., Cordier S., Costet N., Espinosa A., Grazuleviciene R., Danileviciute A., Ibarluzea J., Karadanelli M., Krasner S., Patelarou E., Stephanou E., Tardon A., Toledano M.B, Wright J., Villanueva C.M, Nieuwenhuijsen M.
Date Published07/2016
ISBN Number1044-3983
Accession Number27468006

BACKGROUND: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (HiWate). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. METHODS: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities were recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. RESULTS: Average levels of trihalomethanes ranged from around 10mug/L to above the regulatory limits in the EU of 100 mug/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (beta= 2.2 g in birth weight per 10mug/L of THM, 95%CI -3.3, 7.6). Birthweight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (OR per 10mug/L=1.02, 95%CI 0.95, 1.10), small-for-gestational age (OR=0.99, 0.94, 1.03) and preterm births (OR= 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. CONCLUSIONS: In this large European study we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.

Short TitleEpidemiology
Alternate JournalEpidemiology (Cambridge, Mass.)