Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study

TitleCord Blood Metabolic Signatures of Birth Weight: A Population-Based Study
Publication TypeJournal Article
Year of Publication2018
AuthorsRobinson O., Keski-Rahkonen P., Chatzi L., Kogevinas M., Nawrot T., Pizzi C., Plusquin M., Richiardi L., Robinot N., Sunyer J., Vermeulen R., Vrijheid M., Vineis P., Scalbert A., Chadeau-Hyam M.
JournalJ Proteome ResJournal of Proteome ResearchJournal of Proteome Research
Volume17
Pagination1235-1247
Date PublishedMar 2
ISBN Number1535-3893
Accession Number29401400
Keywords*Birth Weight, *cord blood, *fetal growth, *metabolism, *metabolomics, *pathway perturbation
Abstract

Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. We applied untargeted mass-spectrometry-based metabolomics to 481 cord blood samples collected at delivery in four birth cohorts from across Europe: ENVIRONAGE (Belgium), INMA (Spain), Piccolipiu (Italy), and Rhea (Greece). We performed a metabolome-wide association scan for birth weight on over 4000 metabolic features, controlling the false discovery rate at 5%. Annotation of compounds was conducted through reference to authentic standards. We identified 68 metabolites significantly associated with birth weight, including vitamin A, progesterone, docosahexaenoic acid, indolelactic acid, and multiple acylcarnitines and phosphatidylcholines. We observed enrichment (p < 0.05) of the tryptophan metabolism, prostaglandin formation, C21-steroid hormone signaling, carnitine shuttle, and glycerophospholipid metabolism pathways. Vitamin A was associated with both maternal smoking and birth weight, suggesting a mediation pathway. Our findings shed new light on the pathways central to fetal growth and will have implications for antenatal and perinatal care and potentially for health in later life.

Short TitleJ. Proteome Res.J. Proteome Res.
Alternate JournalJournal of proteome research