Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort.

TitleCirculating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort.
Publication TypeJournal Article
Year of Publication2018
AuthorsMatejcic M, Lesueur F, Biessy C, Renault AL, Mebirouk N, Yammine S, Keski-Rahkonen P, Li K, Hémon B, Weiderpass E, Rebours V, Boutron-Ruault MC, Carbonnel F, Kaaks R, Katzke V, Kuhn T, Boeing H, Trichopoulou A, Palli D, Agnoli C, Panico S, Tumino R, Sacerdote C, Quirós JR, Duell EJ, Porta M, Sánchez MJ, Chirlaque MD, Barricarte A, Amiano P, Ye W, Peeters PH, Khaw KT, Perez-Cornago A, Key TJ, Bueno-de-Mesquita HB, Riboli E, Vineis P, Romieu I, Gunter MJ, Chajès V
JournalInt J Cancer
Volume143
Issue10
Pagination2437-2448
Date Published2018 Nov 15
ISSN1097-0215
Abstract

There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (OR [odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41-0.98; p = 0.036), n-3 polyunsaturated α-linolenic acid (OR = 0.60; 95%CI = 0.39-0.92; p = 0.02) and docosapentaenoic acid (OR = 0.52; 95%CI = 0.32-0.85; p = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (OR = 3.00; 95%CI = 1.13-7.99; p = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (OR = 0.37; 95%CI = 0.17-0.81; p = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (OR = 3.40; 95%CI = 1.39-8.34; p = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

DOI10.1002/ijc.31797
Alternate JournalInt. J. Cancer
PubMed ID30110135
Grant ListFI20121205556 / / Fondation ARC pour la Recherche sur le Cancer /
2013-140 / / Institut National Du Cancer /
2013/987 / / World Cancer Research Fund /
2013-140 / / Institut National du Cancer (INCA) /
2013/987 / / World Cancer Research Funds (WCRF) /
FI20121205556 / / Fondation ARC /
/ / European Commission FP7 Marie Curie Actions-People-Cofunding /
/ / International Agency for Research on Cancer /
/ / Postdoctoral Fellowship /
MR/M012190/1 / / Medical Research Council / United Kingdom
1000143 / / Medical Research Council / United Kingdom
C8221/A19170 / / Cancer Research UK / United Kingdom
C570/A16491 / / Cancer Research UK / United Kingdom
14136 / / Cancer Research UK / United Kingdom
/ / Swedish Cancer Society, Swedish Scientific Council and County Councils of Skåne and Västerbotten (Sweden) /
RD06/0020 / / Navarra, ISCIII RETIC /
6236 / / Regional Governments of Andalucía, Asturias, Basque Country, Murcia /
PI13/00061 / / Health Research /
/ / Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway) /
/ / Statistics Netherlands (The Netherlands) /
/ / World Cancer Research Fund (WCRF) /
/ / Dutch ZON (Zorg Onderzoek Nederland) /
/ / Dutch Prevention Funds /
/ / LK Research Funds /
/ / Netherlands Cancer Registry (NKR) /
/ / Welfare and Sports (VWS) /
/ / Dutch Ministry of Public Health /
/ / National Research Council (Italy) /
/ / Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy /
/ / The Hellenic Health Foundation (Greece) /
/ / Federal Ministry of Education and Research (BMBF, Germany) /
/ / German Cancer Research Center (DKFZ) /
/ / German Cancer Aid /
/ / Institut National de la Santé et de la Recherche Médicale (INSERM) (France) /
/ / Mutuelle Générale de l'Education Nationale /
/ / Institut Gustave Roussy /
/ / Ligue Contre le Cancer /
/ / Danish Cancer Society (Denmark) /
/ / International Agency for Research on Cancer /
/ / The European Commission (DG-SANCO) /