The added value of genetic information in colorectal cancer risk prediction models: development and evaluation in the UK Biobank prospective cohort study.

TitleThe added value of genetic information in colorectal cancer risk prediction models: development and evaluation in the UK Biobank prospective cohort study.
Publication TypeJournal Article
Year of Publication2018
AuthorsSmith T, Gunter MJ, Tzoulaki I, Muller DC
JournalBr J Cancer
Volume119
Issue8
Pagination1036-1039
Date Published2018 Oct
ISSN1532-1827
Abstract

Colorectal cancer (CRC) risk prediction models could be used to risk-stratify the population to provide individually tailored screening provision. Using participants from the UK Biobank prospective cohort study, we evaluated whether the addition of a genetic risk score (GRS) could improve the performance of two previously validated models. Inclusion of the GRS did not appreciably improve discrimination of either model, and led to substantial miscalibration. Following recalibration the discrimination did not change, but good calibration for models incorporating the GRS was recovered. Comparing predictions between models with and without the GRS, 5% of participants or fewer changed their absolute risk by ±0.3% or more in either model. In summary, addition of a GRS did not meaningfully improve the performance of validated CRC-risk prediction models. At present, provision of genetic information is not useful for risk stratification for CRC.

DOI10.1038/s41416-018-0282-8
Alternate JournalBr. J. Cancer
PubMed ID30323197
Grant ListMR/M501712/1 / / Medical Research Council (MRC) /
C57955/A24390 / / Cancer Research UK (CRUK) /