2014-05

  • Metabolome-based molecular phenotyping of complex diseases
    Dr Dominique Gauguier
    29 May, 2014
    Stamford Street Lecture Theatre
    Waterloo Campus
    United Kingdom
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    Metabolome-based molecular phenotyping of complex diseases
    (
    Speaker: Dr Dominique Gauguier)
    Annual Distinguished Guest Lecture at annual International Scientific Advisory Board meeting 

     

    THURSDAY 29 MAY 2014 - 5.30pm – 6.30pm followed by drinks reception
    Stamford Street Lecture Theatre, Franklin Wilkins Building, King’ College London, Waterloo, London SE1

     

    Abstract: Even though genome-wide association studies (GWAS) of complex disorders have been successful in identifying novel genetic targets, these loci explain only a small proportion of disease heritability. Phenotype heterogeneity, environmental influences and gene-environment interactions contribute to reduce the power of GWAS. The presentation will address recent work combining genetic studies and high throughput molecular phenotyping derived by genome-wide gene expression profiling methods that demonstrates the power of metabolomic methods to identify environment-responsive and disease predictive biomarkers.

     

    Biosketch: Dominique Gauguier is INSERM Director of Research at the Cordeliers Research Centre in Paris, where he leads a team working on the genetic regulation of molecular phenotypes in model systems. He was trained at the University Pierre & Marie Curie in Paris where he received a PhD in human nutrition. He joined the Wellcome Trust Centre for Human Genetics at the University of Oxford where he became Professor of mammalian genetics supported by Wellcome Trust Senior Fellowships between 1999 and 2010. His projects aim at developing integrated strategies to understand genetic and epigenetic regulations of multimodal dynamic gene expression and the impact of the gut microbiome in the regulation of complex phenotypes.